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dc.contributor.authorPérez Solsona, Sandra-
dc.contributor.authorBarceló, Damià-
dc.date.accessioned2009-02-10T11:47:15Z-
dc.date.available2009-02-10T11:47:15Z-
dc.date.issued2007-05-17-
dc.identifier.citationTrAC-Trends in Analytical Chemistry 26(6): 494-514 (2007)en_US
dc.identifier.issn0167-2940-
dc.identifier.urihttp://hdl.handle.net/10261/10524-
dc.description21 pages, 3 figures, 2 tables.-- Printed version published Jun 2007.-- Issue title: Pharmaceutical-residue analysis.en_US
dc.description.abstractThis overview reviews current knowledge on identification, presence and distribution of drug metabolites in the environment. We compare the metabolic routes of environmentally relevant pharmaceuticals in the human body to those of biotransformations brought about by mixed consortia of microorganisms in natural and engineered wastewaters and surface waters. We describe the characteristics of modern mass-spectrometric instrumentation coupled to liquid-chromatographic separation techniques and review their application in profiling metabolites. We set out analytical methodologies for quantitative analysis of drugs and their degradates in sewage and surface waters and give results of monitoring obtained from their application.en_US
dc.description.sponsorshipThe work described in this article was supported by the EU Project EMCO-INCO-CT-2004-509188) and by the Spanish Ministerio de Educación y Ciencia Project EVITA (CTM2004-06255-CO3-01). SP acknowledges a postdoctoral postdoctoral contract from I3P (Itinerario Integrado de Inserción Profesional) Program, co-financed by CSIC and the European Social Fund.en_US
dc.format.extent162 bytes-
dc.format.mimetypeapplication/msword-
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.rightsclosedAccessen_US
dc.subjectEnvironmental analysisen_US
dc.subjectIdentificationen_US
dc.subjectLiquid chromatography-Mass spectrometry (LC-MS)en_US
dc.subjectMetaboliteen_US
dc.subjectMicrobial degradationen_US
dc.subjectPharmaceuticalen_US
dc.subjectSewageen_US
dc.titleApplication of advanced MS techniques to analysis and identification of human and microbial metabolites of pharmaceuticals in the aquatic environmenten_US
dc.typeartículoen_US
dc.identifier.doi10.1016/j.trac.2007.05.004-
dc.description.peerreviewedPeer revieweden_US
dc.relation.publisherversionhttp://dx.doi.org/10.1016/j.trac.2007.05.004en_US
Appears in Collections:(IDAEA) Artículos
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