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Application of advanced MS techniques to analysis and identification of human and microbial metabolites of pharmaceuticals in the aquatic environment

AutorPérez Solsona, Sandra; Barceló, Damià
Palabras claveEnvironmental analysis
Liquid chromatography-Mass spectrometry (LC-MS)
Microbial degradation
Fecha de publicación17-may-2007
CitaciónTrAC-Trends in Analytical Chemistry 26(6): 494-514 (2007)
ResumenThis overview reviews current knowledge on identification, presence and distribution of drug metabolites in the environment. We compare the metabolic routes of environmentally relevant pharmaceuticals in the human body to those of biotransformations brought about by mixed consortia of microorganisms in natural and engineered wastewaters and surface waters. We describe the characteristics of modern mass-spectrometric instrumentation coupled to liquid-chromatographic separation techniques and review their application in profiling metabolites. We set out analytical methodologies for quantitative analysis of drugs and their degradates in sewage and surface waters and give results of monitoring obtained from their application.
Descripción21 pages, 3 figures, 2 tables.-- Printed version published Jun 2007.-- Issue title: Pharmaceutical-residue analysis.
Versión del editorhttp://dx.doi.org/10.1016/j.trac.2007.05.004
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