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LC-MS for identifying photodegradation products of pharmaceuticals in the environment

AuthorsPetrovic, Mira ; Barceló, Damià
KeywordsLiquid chromatography
Mass spectrometry
Transformation product
Issue Date24-Feb-2007
CitationTrAC-Trends in Analytical Chemistry 26(6): 486-493 (2007)
AbstractAbiotic processes, such as direct and indirect photolysis, are of great importance in determining the aquatic fate of pharmaceutical compounds. Photolytic reactions are often complex, involving various competing or parallel pathways and leading to multiple reaction products. The identification of transformation products and the elucidation of photolysis-reaction pathways are of crucial importance in understanding their fate in the aquatic environment, but are complicated and cumbersome.
This article focuses on advanced liquid chromatography-mass spectrometry (LC-MS) methods for identifying transformation products of abiotic processes that lead to the transformation of pharmaceutical compounds in environmental systems (direct and indirect photolysis) and photocatalytic transformations in water- and wastewater-treatment systems, using titanium dioxide or the photo-Fenton process.
We discuss the capabilities and the limitations of single-MS, tandem-MS and hybrid-MS techniques, and present practical examples (triple-quadrupole-MS analysis of phototransformation products of fluoxetine, ion-trap-MS analysis of photoproducts of carbamazepine, and time-of-flight-MS elucidation of the reaction pathways of photolytic and photocatalytic degradation of diclofenac).
Description8 pages, 4 figures, 1 table.-- Printed version published Jun 2007.-- Issue title: Pharmaceutical-residue analysis.
Publisher version (URL)http://dx.doi.org/10.1016/j.trac.2007.02.010
Appears in Collections:(IDAEA) Artículos
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