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Título

LC-MS for identifying photodegradation products of pharmaceuticals in the environment

AutorPetrovic, Mira; Barceló, Damià
Palabras claveLiquid chromatography
Mass spectrometry
Pharmaceuticals
Photodegradation
Transformation product
Fecha de publicación24-feb-2007
EditorElsevier
CitaciónTrAC-Trends in Analytical Chemistry 26(6): 486-493 (2007)
ResumenAbiotic processes, such as direct and indirect photolysis, are of great importance in determining the aquatic fate of pharmaceutical compounds. Photolytic reactions are often complex, involving various competing or parallel pathways and leading to multiple reaction products. The identification of transformation products and the elucidation of photolysis-reaction pathways are of crucial importance in understanding their fate in the aquatic environment, but are complicated and cumbersome.
This article focuses on advanced liquid chromatography-mass spectrometry (LC-MS) methods for identifying transformation products of abiotic processes that lead to the transformation of pharmaceutical compounds in environmental systems (direct and indirect photolysis) and photocatalytic transformations in water- and wastewater-treatment systems, using titanium dioxide or the photo-Fenton process.
We discuss the capabilities and the limitations of single-MS, tandem-MS and hybrid-MS techniques, and present practical examples (triple-quadrupole-MS analysis of phototransformation products of fluoxetine, ion-trap-MS analysis of photoproducts of carbamazepine, and time-of-flight-MS elucidation of the reaction pathways of photolytic and photocatalytic degradation of diclofenac).
Descripción8 pages, 4 figures, 1 table.-- Printed version published Jun 2007.-- Issue title: Pharmaceutical-residue analysis.
Versión del editorhttp://dx.doi.org/10.1016/j.trac.2007.02.010
URIhttp://hdl.handle.net/10261/10518
DOI10.1016/j.trac.2007.02.010
ISSN0167-2940
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