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dc.contributor.authorManga-González, M. Yolanda-
dc.contributor.authorFerreras, Mª del Carmen-
dc.contributor.authorCampo, Raquel-
dc.contributor.authorGonzález Lanza, Camino-
dc.contributor.authorPérez Pérez, Valentín-
dc.contributor.authorGarcía Marín, Juan Francisco-
dc.date.accessioned2009-02-10T08:53:08Z-
dc.date.available2009-02-10T08:53:08Z-
dc.date.issued2004-
dc.identifier.citationParasitology Research 93(5): 344-355 (2004)en_US
dc.identifier.issn0932-0113-
dc.identifier.urihttp://hdl.handle.net/10261/10480-
dc.description12 pages, 5 figures.-- PMID: 15197580 [PubMed].-- Available online 10 Jun 2004.en_US
dc.description.abstractHepatic enzymes and biochemical parameter values were analysed in the sera of 32 lambs: 12 infected with 1,000 Dicrocoelium dendriticum metacercariae, 12 with 3,000 and eight controls. Blood samples were collected at intervals of 30 days from day 0 post-infection (p.i.). Half the lambs in each group were slaughtered on days 60 and 180 p.i, respectively. A histopathological and ultrastructural study was carried out on the liver, gall bladder and hepatic lymph nodes of all animals. A minute increase was detected in the bilirubin (7%) and albumin (3%) values in the infected lambs (with 30–2,063 worms) in comparison with those of the controls. The hepatic enzyme values did increase, above all aspartate aminotransferase (19%) and alanine aminotransferase (22%), mainly in the lambs tested with 3,000 metacercariae (38% and 48%, respectively). The increase was significant 60 days p.i. The severity of the lesions was closely associated with the parasite burden.en_US
dc.description.sponsorshipThis study was supported by the Spanish CICYT (Projects nos. AGF92-0588 and AGL2001-1290). The experiments carried out with lambs in this study comply with current Spanish law on animal experimentation.en_US
dc.format.extent94510 bytes-
dc.format.mimetypeapplication/pdf-
dc.language.isoengen_US
dc.publisherSpringeren_US
dc.rightsclosedAccessen_US
dc.subjectLeón Provinceen_US
dc.subjectMast-cellsen_US
dc.subjectNW Spainen_US
dc.subjectSheepen_US
dc.subjectLiveren_US
dc.subjectDicroceliosisen_US
dc.subjectHistopathologyen_US
dc.subjectFascioliasisen_US
dc.subjectEliminationen_US
dc.subjectPrevalenceen_US
dc.titleHepatic marker enzymes, biochemical parameters and pathological effects in lambs experimentally infected with Dicrocoelium dendriticum (Digenea)en_US
dc.typeartículoen_US
dc.identifier.doihttp://dx.doi.org/10.1007/s00436-004-1128-2-
dc.description.peerreviewedPeer revieweden_US
dc.relation.publisherversionhttp://dx.doi.org/10.1007/s00436-004-1128-2en_US
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