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Malignant fibrous histiocytoma (giant cell type) associated with a malignant mixed tumor in the salivary gland of a dog

AutorPérez, C.; García, R. A.; Reyes, L. E.; Pérez Pérez, Valentín ; González, N.; García, M. J.
Palabras claveMalignant fibrous histiocytoma (giant cell type)
Mixed tumor
Salivary grand
Immunohistochemistry
Does
Fecha de publicación2000
EditorSage Publications
CitaciónVeterinary Pathology 37: 350-353 (2000)
ResumenA 12-year-old male Boxer dog presented with a 5 X 5 X 7-cm partially encapsulated mass in the right mandibular salivary gland. Histologically, the mass was composed of neoplastic epithelial and mesenchymal cells. The mesenchymal component consisted of two cell populations arranged in different patterns: coalescing nodules of neoplastic mononuclear cells with rare osteoid and numerous osteoclastlike giant cells; and sheets of neoplastic spindle cells intermingled with neoplastic epithelial cells and containing osteoid and well-formed bone trabeculae lined by osteoblasts and few osteoclastlike giant cells. On the basis of these histological features, two malignant salivary tumors were diagnosed: a malignant fibrous histiocytoma (giant cell type! and a malignant mixed tumor. Immunohistochemical studies demonstrated keratin 5 and 8 expression by the neoplastic epithelial cells, indicating a probable salivary ductal origin, and vimentin expression by all mesenchymal elements, suggesting a fibroblastic line of differentiation.
Descripción4 páginas, 3 figuras.
Versión del editorhttp://dx.doi.org/10.1354/vp.37-4-350
URIhttp://hdl.handle.net/10261/104165
DOI10.1354/vp.37-4-350
ISSN0300-9858
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