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Kinetics and mechanism of bioreduction of nitrimidazoles as hypoxia probes

AuthorsPacheco-Torres, Jesús CSIC ORCID ; Ballesteros, Paloma ORCID; López-Larrubia, Pilar CSIC ORCID; Cerdán, Sebastián CSIC ORCID
Issue Date2013
CitationISMRM 2013
Abstract2-Nitroimidazole derivatives have been traditionally used as molecular markers of hypoxia due to their preferential reduction and subsequent trapping in vivo under hypoxic conditions. However, the reduction mechanism and its rate determining steps remained largely unexplored. We show that it is the intracellular redox state (NADP/NADPH, GSSG/GSH), rather than the oxygen tension by itself, what determines the reduction rate of these compounds, the reaction rate being limited mainly by the GSH concentration. This is a general mechanism occurring in all 2-Nitroimidazole derivatives investigated. Also, we report the appearance and the kinetics of new signals belonging to reaction intermediates.
DescriptionTrabajo presentado al 21th Annual Meeting & Exhibition of International Society for Magnetic Resonance in Medicine, celebrado en Salt Lake City (US) del 20 al 26 de Abril de 2013.
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