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fMRI of hypothalamic activation by fasting in ob/ob mice using T2* and FDWI with high and low B values. A comparative study

AuthorsLizarbe, Blanca ; López-Larrubia, Pilar ; Cerdán, Sebastián
Issue Date2013
CitationISMRM 2013
AbstractObesity is a pandemic syndrome often associated to the most prevalent and morbid pathologies in developed countries. Body adiposity is thought to be regulated systemically through an endocrine ‘adiposity’-negative feedback loop, mainly supported by leptin interacting with hypothalamic nuclei. The leptin-null ob/ob mouse model exhibits decreased energy expenditure, hyperphagia and obesity. In this communication, we wish to characterize the activation by fasting in individual hypothalamic nuclei from ob/ob mice, using DWI at high b values, DWI at low b values and T2* imaging, comparing the results obtained with the three techniques.
DescriptionTrabajo presentado al 21th Annual Meeting & Exhibition of International Society for Magnetic Resonance in Medicine, celebrado en Salt Lake City (US) del 20 al 26 de Abril de 2013.
Publisher version (URL)http://www.ismrm.org/13/ep03.htm
Appears in Collections:(IIBM) Comunicaciones congresos
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