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Early increases in Glu/Gln, Tau and TCho 1H MRS resonances in vivo, anticipate later imaging repercussions of the cerebral inflammatory response in a mouse model of LPS-induced endotoxemia

AuthorsMartín-Recuero, Ana Belen ; Krzyzanowska, Agnieszka; López-Larrubia, Pilar ; Avendaño, Carlos; Cerdán, Sebastián
Issue Date2013
CitationISMRM 2013
AbstractCerebral inflammation underlies the most morbid and prevalent neurological disorders, including cancer, ischemia or neurodegeneration. However, the inflammatory component remains difficult to differentiate from the intrinsic pathology by most bioimaging methods, since in-vivo biomarkers of the inflammatory phenotype have not been characterized. With this aim, we report a longitudinal MRI and MRS characterization of the cerebral inflammatory component developed after systemic administration of LPS, an inflammation model devoid of additional intrinsic pathologies. Our results revealed that inflammation is characterized by early, severe, spectroscopic changes in Glu/Gln, tCho, Tau and Lac resonances, anticipating those detected later by multi-parametric MRI.
DescriptionTrabajo presentado al 21th Annual Meeting & Exhibition of International Society for Magnetic Resonance in Medicine, celebrado en Salt Lake City (US) del 20 al 26 de Abril de 2013.
Publisher version (URL)http://www.ismrm.org/13/session12.htm
Appears in Collections:(IIBM) Comunicaciones congresos
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