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Improved dead-time correction for PET scanners: Application to small-animal PET

Autor Vicente, E.; Herraiz, J.L.; España, S.; Herranz, E.; Desco, Manuel; Vaquero, Juan J.; Udías, J.M.
Palabras clave Non-ionizing radiation equipment and techniques
Positron Emission Tomography (PET)
Image quality
Fecha de publicación 2013
EditorInstitute of Physics Publishing
Citación Physics in Medicine and Biology 58: 2059- 2072 (2013)
ResumenPile-up and dead-time are two main causes of nonlinearity in the response of a PET scanner as a function of activity in the field of view (FOV). For a given scanner and acquisition system, pile-up effects depend on the material and size of the object being imaged and on the distribution of activity inside and outside the FOV, because these factors change the singles-to-coincidences ratio (SCR). Thus, it is difficult to devise an accurate correction that would be valid for any acquisition. In this work, we demonstrate a linear relationship between SCR and effective dead-time, which measures the effects of both dead-time (losses) and pile-up (gains and losses). This relationship allows us to propose a simple method to accurately estimate dead-time and pile-up corrections using only two calibration acquisitions with, respectively, a high and low SCR. The method has been tested with simulations and experimental data for two different scanner geometries: a scanner with large area detectors and no pile-up rejection, and a scanner composed of two full rings of smaller detectors. Our results show that the SCR correction method is accurate within 7%, even for high activities in the FOV, and avoids the bias of the standard single-parameter method. © 2013 Institute of Physics and Engineering in Medicine.
URI http://hdl.handle.net/10261/104060
Identificadoresdoi: 10.1088/0031-9155/58/7/2059
issn: 0031-9155
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