English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/104005
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

Title

Cerebral oedema is not responsible for motor or cognitive deficits in rats with hepatic encephalopathy

AuthorsCauli, Omar; Rodrigues, Tiago B.; López-Larrubia, Pilar ; Cerdán, Sebastián ; Felipo, Vicente
KeywordsMemory
Motor function
Learning
Inflammation
Cytotoxic oedema
Minimal hepatic encephalopathy
Issue Date2014
PublisherJohn Wiley & Sons
CitationLiver International 34(3): 379-387 (2014)
Abstract[Background & Aims]: Low-grade cytotoxic oedema is considered a main contributor to the neurological (motor and cognitive) alterations in patients with hepatic encephalopathy (HE). This assumption is mainly based on studies with cultured astrocytes treated with very large ammonia concentrations or with animal models of acute liver failure with strong HE. However, the possible contribution of cerebral oedema (vasogenic or cytotoxic) to cognitive or motor alterations in chronic mild HE has not been demonstrated. The aim of this work was to assess whether cerebral oedema contributes to cognitive and/or motor alterations in rats with chronic mild HE. [Methods]: Motor activity and coordination and different types of learning and memory were assessed in rats with porta-caval shunts (PCS). Brain oedema was assessed by gravimetry in cerebellum and cortex and apparent diffusion coefficient (ADC) by magnetic resonance in 16 areas. [Results]: Four weeks after surgery, PCS rats show reduced motor activity and coordination, impaired ability to learn a conditional discrimination task in the Y maze and reduced spatial memory in the Morris water maze. PCS rats did not show increased brain water content at 4 or 10 weeks or changes in ADC at 4 weeks. At 10 weeks, increased ADC in some areas is compatible with vasogenic but not cytotoxic oedema. [Conclusion]: Cerebral oedema is not involved in motor and cognitive alterations in rats (and likely in humans) with mild HE. Proper understanding of the mechanisms responsible for the neurological alterations in HE is necessary to design efficient treatments. © 2013 John Wiley & Sons A/S.
Descriptionet al.
URIhttp://hdl.handle.net/10261/104005
DOI10.1111/liv.12258
Identifiersdoi: 10.1111/liv.12258
issn: 1478-3223
e-issn: 1478-3231
Appears in Collections:(IIBM) Artículos
Files in This Item:
File Description SizeFormat 
accesoRestringido.pdf15,38 kBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.