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Título

The Cdc14p phosphatase affects late cell-cycle events and morphogenesis in Candida albicans

Autor González-Novo, Alberto; Sánchez-Pérez, Miguel; Vázquez de Aldana, Carlos R.; Jiménez, Javier; Correa-Bordes, Jaime
Palabras clave Cytokinesis
Cell separation
Mitotic exit
ACE2
HGC1
Fecha de publicación 28-feb-2006
EditorCompany of Biologists
Citación Journal of Cell Science 119(6): 1130-1143 (2006)
ResumenWe have characterized the CDC14 gene, which encodes a dual-specificity protein phosphatase in Candida albicans, and demonstrated that its deletion results in defects in cell separation, mitotic exit and morphogenesis. The C. albicans cdc14Δ mutants formed large aggregates of cells that resembled those found in ace2-null strains. In cdc14Δ cells, expression of Ace2p target genes was reduced and Ace2p did not accumulate specifically in daughter nuclei. Taken together, these results imply that Cdc14p is required for the activation and daughter-specific nuclear accumulation of Ace2p. Consistent with a role in cell separation, Cdc14p was targeted to the septum region during the M-G1 transition in yeast-form cells. Interestingly, hypha-inducing signals abolished the translocation of Cdc14p to the division plate, and this regulation depended on the cyclin Hgc1p, since hgc1Δ mutants were able to accumulate Cdc14p in the septum region of the germ tubes. In addition to its role in cytokinesis, Cdc14p regulated mitotic exit, since synchronous cultures of cdc14Δ cells exhibited a severe delay in the destruction of the mitotic cyclin Clb2p. Finally, deletion of CDC14 resulted in decreased invasion of solid agar medium and impaired true hyphal growth.
Descripción 14 pages, 10 figures.-- et al.
Versión del editorhttp://dx.doi.org/10.1242/jcs.02820
URI http://hdl.handle.net/10261/10381
DOI10.1242/jcs.02820
ISSN0021-9533
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