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Título

Receptors of thyroid hormones

Autor Aranda, Ana ; Alonso-Merino, Elvira; Zambrano, Alberto
Palabras clave Thyroid receptors
Thyroid hormones
Fecha de publicación 2013
EditorYS Medical Media
Citación Pediatric Endocrinology Reviews 11(1): 2-13 (2013)
ResumenThe important physiological actions of the thyroid hormones are mediated by binding to nuclear thyroid hormone receptors (TRs), encoded by two genes TRalpha and TRbeta. These receptors act as hormone-dependent transcription factors by binding to DNA motifs located in the regulatory regions of target genes and recruiting coregulators (coactivators and corepresors), which alter chromatin structure. Novel thyromimetics have been developed that bind preferentially TRbeta could be used for treatment of hyperlipidemia and obesity. TRbeta gene mutations cause resistance to thyroid hormones (RTH), characterized by inappropriately high thyroid-stimulating hormone (TSH) levels due to lack of feedback inhibition of thyroid hormones on the hypothalamus and pituitary gland, and to reduced sensitivity of other TRbeta target tissues to thyroid hormones. Very recently, patients heterozygous for TRalpha mutations have been identified. These patients exhibit clinical symptoms of hypothyroidism in TRalpha target tissues such as intestine or hearth and near normal circulating TSH and thyroid hormone levels.
Versión del editorhttp://www.pediatricendoreviews.com/#!volume-111/czph
URI http://hdl.handle.net/10261/103760
Identificadoresissn: 1565-4753
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