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Título

Rapid and simultaneous determination of polychlorinated biphenyls and their main metabolites (hydroxylated and methyl sulfonyl) by gas chromatography coupled to mass spectrometry: Comparison of different ionisation modes

Autor Castro-Puyana, M. ; Herrero, Laura ; González, M. Jesús ; Gómara, Belén
Palabras clave Mass spectrometry
Gas chromatography
Electron capture negative ionisation
Electron impact
Metabolites
Polychlorinated biphenyls
Fecha de publicación 2013
EditorElsevier
Citación Analytica Chimica Acta 787: 148- 154 (2013)
ResumenInstrumental methods based on gas chromatography coupled to mass spectrometry (GC-MS) have been developed and compared using two different MS ionisation modes, electron impact (EI) and electron capture negative ionisation (ECNI), for the fast, quantitative and simultaneous determination of polychlorinated biphenyls (PCBs) and their main metabolites (hydroxylated PCBs, OH-PCBs, and methyl sulfone PCBs, MeSO2-PCBs). Parameters affecting chromatographic separation and MS detection were evaluated in order to achieve the highest selectivity and sensitivity for both operation modes. The analytical characteristics of the developed methods were studied and compared in terms of linear range, limits of detection (LODs), limits of quantification (LOQs), and instrumental precision (repeatability and intermediate precision). Both ionisation methods showed similar precision, being relative standard deviations (RSD, %) lower than 9% and 14% for repeatability and intermediate precision, respectively. However, better LODs (from 0.01 to 0.14pg injected for the three families of congeners studied) were achieved using ECNI-MS as ionisation mode. The suitability of the developed method was demonstrated through their application to fish liver oil samples.
URI http://hdl.handle.net/10261/103748
DOI10.1016/j.aca.2013.05.045
Identificadoresdoi: 10.1016/j.aca.2013.05.045
issn: 0003-2670
e-issn: 1873-4324
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