English   español  
Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/10371
Compartir / Impacto:
Estadísticas
Add this article to your Mendeley library MendeleyBASE
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Título

Synthetic peptides for the immunodiagnosis of human diseases

AutorGómara Elena, María José; Haro Villar, Isabel
Palabras claveSynthetic peptides
Diagnosis
Human diseases
Fecha de publicaciónfeb-2007
EditorBentham Science Publishers
CitaciónCurrent Medicinal Chemistry 14(5): 531-546 (2007)
ResumenSynthetic peptides have been shown to be valuable tools for viral laboratory diagnosis and can provide uniform, chemically well-defined antigens for antibody analysis, reducing inter- and intra-assay variation.
The main aim in the development of peptide-based diagnostic tests is to recognise specific antibodies induced by the whole viral proteins but using selected short fragments containing the most potent antigenic determinants. The success of this approach depends on the extent to which synthetic peptides are able to mimic the immunodominant epitopes of antigens. In recent years, synthetic peptides that mimic specific epitopes of infectious agents’ proteins have been used in diagnostic systems for various human diseases.
The present review summarizes some of the drawbacks of the use of relatively short linear peptides as antigenic substrates and the subsequent chemical strategies developed in order to overcome the low peptide reactivity against specific antibodies. Moreover, it outlines the most significant bibliography published in the last five years which provides validated peptide based tests potentially useful for diagnosis of viral, bacterial, parasitic and autoimmune diseases.
Descripción16 pages, 3 figures, 3 tables.-- PMID: 17346145 [PubMed].
Versión del editorhttp://dx.doi.org/10.2174/092986707780059698
URIhttp://hdl.handle.net/10261/10371
DOI10.2174/092986707780059698
ISBN1875-533x (Online)
ISSN0929-8673 (Print)
Aparece en las colecciones: (IQAC) Artículos
Ficheros en este ítem:
No hay ficheros asociados a este ítem.
Mostrar el registro completo
 

Artículos relacionados:


NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.