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Título

Schistosoma bovis: Plasminogen binding in adults and the identification of plasminogen-binding proteins from the worm tegument

AutorRamajo Hernández, Alicia ; Pérez Sánchez, Ricardo ; Ramajo Martín, Vicente ; Oleaga, Ana
Palabras claveSchistosoma bovis
Tegument
Plasminogen binding
Proteome
Mass spectrometry
Confocal microscopy
Fecha de publicaciónene-2007
EditorElsevier
CitaciónExperimental Parasitology 115(1): 83-91 (2007)
ResumenSchistosoma bovis is a ruminant haematic parasite that lives for years in the mesenteric vessels of the host. The aim of this work was to investigate the ability of adult S. bovis worms to interact with plasminogen, a central component in the host fibrinolytic system. Confocal microscopy analysis revealed that plasminogen bound to the tegument surface of the male—but not female—S. bovis worms and that this binding was strongly dependent on lysine residues. It was also observed that a protein extract of the worm tegument (TG) had the capacity to generate plasmin and to enhance the plasmin generation by the tissue-type plasminogen activator. Proteomic analysis of the TG extract identified 10 plasminogen-binding proteins, among which the major ones were enolase, glyceraldehyde-3-phosphate dehydrogenase and actin. This study represents the first report about the binding of plasminogen to Schistosoma sp. proteins.
Descripción9 pages, 5 figures.-- PMID: 16962583 [PubMed].-- Available online Sep 8, 2006.
Versión del editorhttp://dx.doi.org/10.1016/j.exppara.2006.07.003
URIhttp://hdl.handle.net/10261/10342
DOI10.1016/j.exppara.2006.07.003
ISSN0014-4894
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