English   español  
Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/103149
Compartir / Impacto:
Estadísticas
Add this article to your Mendeley library MendeleyBASE
Ver citas en Google académico
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar otros formatos: Exportar EndNote (RIS)Exportar EndNote (RIS)Exportar EndNote (RIS)
Título

Detection of Amyloid Marker Thioflavin T on Ag Nanoparticles by Surface-Enhanced Raman Scattering

Autor Fabriciova, G.; López-Tobar, Eduardo ; Antalik, Marian; Jancura, Daniel; Cañamares, María Vega; García-Leis, Adianez ; Fedunova, Diana; Sánchez-Cortés, Santiago
Fecha de publicación 2013
EditorSpringer
Citación 9th EBSA European Biophysics Congress, Lisbon, Portugal, 13-17 July 2013
ResumenThe vibrational characterization of the dye used for detection of amyloid aggregates Thioflavin T (ThT) was carried out by means of Raman and surface-enhanced Raman scattering (SERS). The Raman spectrum of ThT in aqueous solution correlates very well with the spectrum of ThT with the torsional angle between the benzothiazole (BT) and dimethylaminobenzene (DMB) moieties of 37¿ calculated using DFT calculations at the B3LYP/6-31+G** level. The SERS technique was very useful for the detection of two structures of ThT molecules in the vicinity of the metal nanoparticles: directly adsorbed onto the metal surface and molecules forming multilayers. The structure of ThT molecules in multilayers is similar to the structure of free ThT in aqueous solution. The molecules directly adsorbed on the metal surface actually correspond to the molecules with 90¿ torsional angle between the BT and DMB rings.
URI http://hdl.handle.net/10261/103149
DOI10.1007/s00249-013-0917-x
Identificadoresdoi: 10.1007/s00249-013-0917-x
Aparece en las colecciones: (CFMAC-IEM) Comunicaciones congresos
Ficheros en este ítem:
Fichero Descripción Tamaño Formato  
accesoRestringido.pdf15,38 kBAdobe PDFVista previa
Visualizar/Abrir
Mostrar el registro completo
 


NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.