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Título

NIR excitation of upconversion nanohybrids containing a surface grafted Bodipy induces oxygen-mediated cancer cell death

Autor González-Béjar, María; Liras, Marta ; Francés-Soriano, Laura; Voliani, Valerio; Durán-Moreno, María; García-Verdugo, José M.; Alarcón, Emilio I.; Scaiano, Juan C.; Pérez-Prieto, Julia; Herranz-Pérez, Vicente
Fecha de publicación 2014
EditorRoyal Society of Chemistry (Great Britain)
Citación Journal of Materials Chemistry B 2: 4554- 4563 (2014)
ResumenWe report the preparation of water-dispersible, ca. 30 nm-sized nanohybrids containing NaYF4:Er3+, Yb3+ up-conversion nanoparticles (UCNPs), capped with a polyethylene glycol (PEG) derivative and highly loaded with a singlet oxygen photosensitizer, specifically a diiodo-substituted Bodipy (IBDP). The photosensitizer, bearing a carboxylic group, was anchored to the UCNP surface and, at the same time, embedded in the PEG capping; the combined action of the UCNP surface and PEG facilitated the loading for an effective energy transfer and, additionally, avoided photosensitizer leaching from the nanohybrid (UCNP-IBDP@PEG). The effectiveness of the nanohybrids in generating singlet oxygen after near-infrared (NIR) excitation (975 nm) with a continuous wavelength (CW) laser was evidenced by using a probe molecule. In vitro assays demonstrated that the UCNP-IBDP@PEG nanohybrid was taken up by the SH-SY5Y human neuroblastoma-derived cells showing low cytotoxicity. Moreover, ca. 50% cancer cell death was observed after NIR irradiation (45 min, 239 mW).
URI http://hdl.handle.net/10261/103023
DOI10.1039/c4tb00340c
Identificadoresdoi: 10.1039/c4tb00340c
issn: 2050-750X
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