English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/102922
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:


Experimental infection of house sparrows (Passer domesticus) with West Nile virus strains of lineages 1 and 2

AuthorsDel Amo, Javier; Llorente, Francisco; Pérez-Ramírez, Elisa ; Soriguer, Ramón C. ; Figuerola, Jordi ; Nowotny, N.; Jiménez-Clavero, Miguel A.
KeywordsHost competence
House sparrow
WNV lineage 1 and 2
Experimental infection
West Nile virus
Issue Date2014
CitationVeterinary Microbiology 172: 542- 547 (2014)
AbstractWest Nile virus (WNV) is a zoonotic pathogen which is maintained in an enzootic cycle between mosquitoes and birds; humans, equines, other mammals and some bird species are dead-end hosts. Lineage 1 WNV strains have predominated in Europe since the 1960s. However, in 2004 lineage 2 strains emerged in Hungary and Russia, respectively, spreading since then to a number of neighbouring countries (e.g., Austria, Greece, Italy, Serbia and Romania). Wild bird mortality is a hallmark of North American WNV outbreaks, a feature uncommon in Europe. This study aimed to compare the course of infection of lineage 1 (NY99) and lineage 2 (Austria/2008) WNV strains in the house sparrow, a bird species common in Europe and North America. House sparrows were inoculated with either NY99 or Austria/2008 WNV strains, or sham-inoculated, and clinical and analytic parameters (viraemia, viral load, antibodies) were examined until 14 days after inoculation. Although all inoculated sparrows became infected, no mortality or clinical signs were observed due to the infection. However, the magnitude and duration of viraemia were higher for NY99 - than for Austria/2008 - infected birds. The house sparrow proved to be a competent host for both strains, although the competence index calculated for NY99 was higher than for Austria/2008. Viral load in tissues and swabs was also higher in NY99-inoculated sparrows. In conclusion, the house sparrow is a convenient avian model for studying host competence of WNV strains. The observed differences between NY99 and Austria/2008 strains might have important epidemiological consequences for disease incidence and dispersal capacity. © 2014 Elsevier B.V.
Identifiersdoi: 10.1016/j.vetmic.2014.06.005
issn: 1873-2542
Appears in Collections:(EBD) Artículos
Files in This Item:
File Description SizeFormat 
WNV WNV L1 L2 Sparrows R1_corr_clean.pdf117,34 kBAdobe PDFThumbnail
Table 1.docx14,09 kBMicrosoft Word XMLView/Open
Table 2.docx17,63 kBMicrosoft Word XMLView/Open
Figure 1_rev.tif173,51 kBTIFFThumbnail
Figura 2_rev.tif116,52 kBTIFFThumbnail
Show full item record
Review this work

Related articles:

WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.