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http://hdl.handle.net/10261/102902
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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | García-Valtanen, Pablo | es_ES |
dc.contributor.author | Ortega-Villaizán, M. M. | es_ES |
dc.contributor.author | Martínez-López, Alicia | es_ES |
dc.contributor.author | Medina-Gali, Regla María | es_ES |
dc.contributor.author | Pérez, L. | es_ES |
dc.contributor.author | Mackenzie, Simon | es_ES |
dc.contributor.author | Figueras Huerta, Antonio | es_ES |
dc.contributor.author | Coll Morales, Julio | es_ES |
dc.contributor.author | Estepa, Amparo | es_ES |
dc.date.issued | 2014 | - |
dc.identifier.citation | Autophagy 10(9): 1666-1680 (2014) | es_ES |
dc.identifier.issn | 1554-8627 | - |
dc.identifier.uri | http://hdl.handle.net/10261/102902 | - |
dc.description | 15 páginas, 7 figuras, 1 tabla.-- This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited | es_ES |
dc.description.abstract | It has not been elucidated whether or not autophagy is induced by rhabdoviral G glycoproteins (G) in vertebrate organisms for which rhabdovirus infection is lethal. Our work provides the first evidence that both mammalian (vesicular stomatitis virus, VSV) and fish (viral hemorrhagic septicemia virus, VHSV, and spring viremia carp virus, SVCV) rhabdoviral Gs induce an autophagic antiviral program in vertebrate cell lines. The transcriptomic profiles obtained from zebrafish genetically immunized with either Gsvcv or Gvhsv suggest that autophagy is induced shortly after immunization and therefore, it may be an important component of the strong antiviral immune responses elicited by these viral proteins. Pepscan mapping of autophagy-inducing linear determinants of Gvhsv and Gvsv showed that peptides located in their fusion domains induce autophagy. Altogether these results suggest that strategies aimed at modulating autophagy could be used for the prevention and treatment of rhabdoviral infections such as rabies, which causes thousands of human deaths every year. | es_ES |
dc.description.sponsorship | This work was supported by the Spanish Ministry of Economy and Competence’s grants AGL2011-28921-C03 and CONSOLIDER INGENIO 2010-CSD2007-00002 as well as by the Generalitat Valenciana’s grant ISIC-2012-003 ACOMP/2013/230. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Landes Bioscience | es_ES |
dc.relation.isversionof | Publisher's version | es_ES |
dc.rights | openAccess | es_ES |
dc.subject | Antiviral | es_ES |
dc.subject | Autophagy | es_ES |
dc.subject | Immune response | es_ES |
dc.subject | LC3 | es_ES |
dc.subject | Microarrays | es_ES |
dc.subject | Pepscan | es_ES |
dc.subject | Rhabdovirus | es_ES |
dc.subject | SVCV | es_ES |
dc.subject | VHSV | es_ES |
dc.subject | Viral glycoprotein | es_ES |
dc.subject | VSV | es_ES |
dc.subject | Zebrafish | es_ES |
dc.title | Autophagy-inducing peptides from mammalian VSV and fish VHSV rhabdoviral G glycoproteins (G) as models for the development of new therapeutic molecules | es_ES |
dc.type | artículo | es_ES |
dc.identifier.doi | 10.4161/auto.29557 | - |
dc.description.peerreviewed | Peer reviewed | es_ES |
dc.relation.publisherversion | http://dx.doi.org/10.4161/auto.29557 | es_ES |
dc.identifier.e-issn | 1554-8635 | - |
dc.rights.license | http://creativecommons.org/licenses/by-nc/3.0/ | es_ES |
dc.relation.csic | Sí | es_ES |
dc.identifier.pmid | 25046110 | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairetype | artículo | - |
item.grantfulltext | open | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | With Fulltext | - |
item.languageiso639-1 | en | - |
Aparece en las colecciones: | (IIM) Artículos (INIA) Artículos |
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Autophagy_inducing_peptides.pdf | 3,83 MB | Adobe PDF | Visualizar/Abrir |
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