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Title

Autophagy-inducing peptides from mammalian VSV and fish VHSV rhabdoviral G glycoproteins (G) as models for the development of new therapeutic molecules

AuthorsGarcía-Valtanen, Pablo; Ortega-Villaizán, M. del Mar ; Martínez-López, Alicia; Medina-Gali, Regla María; Pérez, Luis; MacKenzie, Simon; Figueras Huerta, Antonio ; Coll, Julio; Estepa, Amparo
KeywordsAntiviral
Autophagy
Immune response
LC3
Microarrays
Pepscan
Rhabdovirus
SVCV
VHSV
Viral glycoprotein
VSV
Zebrafish
Issue Date2014
PublisherLandes Bioscience
CitationAutophagy 10(9): 1666-1680 (2014)
AbstractIt has not been elucidated whether or not autophagy is induced by rhabdoviral G glycoproteins (G) in vertebrate organisms for which rhabdovirus infection is lethal. Our work provides the first evidence that both mammalian (vesicular stomatitis virus, VSV) and fish (viral hemorrhagic septicemia virus, VHSV, and spring viremia carp virus, SVCV) rhabdoviral Gs induce an autophagic antiviral program in vertebrate cell lines. The transcriptomic profiles obtained from zebrafish genetically immunized with either Gsvcv or Gvhsv suggest that autophagy is induced shortly after immunization and therefore, it may be an important component of the strong antiviral immune responses elicited by these viral proteins. Pepscan mapping of autophagy-inducing linear determinants of Gvhsv and Gvsv showed that peptides located in their fusion domains induce autophagy. Altogether these results suggest that strategies aimed at modulating autophagy could be used for the prevention and treatment of rhabdoviral infections such as rabies, which causes thousands of human deaths every year.
Description15 páginas, 7 figuras, 1 tabla.-- This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited
Publisher version (URL)http://dx.doi.org/10.4161/auto.29557
URIhttp://hdl.handle.net/10261/102902
DOI10.4161/auto.29557
ISSN1554-8627
E-ISSN1554-8635
Appears in Collections:(IIM) Artículos
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