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Biodegradable Bi-layered coating on polymeric orthopaedic implants for controlled release of drugs

AutorArgarate, Nerea; Olalde, Beatriz.; Atorrasagasti, Garbiñe.; Valero, Jesús; Cifuentes, Sandra Carolina.; Benavente, Rosario ; Lieblich, Marcela ; González-Carrasco, José Luis
Palabras claveDip coating
Biodegradable polymers
Orthopaedic implants
Controlled release
Fecha de publicación2014
EditorElsevier
CitaciónMaterials Letters 132: 193 - 195 (2014)
ResumenA novel bone substitute incorporating biodegradable coatings on poly(d,l-lactide-co-lactide) (PLDL) implant has been developed. The polymer coatings were investigated as carrier of eugenol (EG) and dexamethasone (DM) which are suitable drugs to give antibacterial and anti-inflammatory function to the implant. The dip coating method was employed to coat the PLDL implant with poly(l-lactic acid) (PLLA) polymer. It has been observed that the thickness of the coating increased with the polymer concentration and the repetition of the dipping process showed an additive coating thickness compared to the single dipping. Moreover, it has been proved that a sequential drug release of EG and DM has been reached by incorporating the drugs onto each layer coating.
URIhttp://hdl.handle.net/10261/102705
DOI10.1016/j.matlet.2014.06.070
Identificadoresdoi: 10.1016/j.matlet.2014.06.070
issn: 0167-577X
e-issn: 1873-4979
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