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Effects of Alprazolam on cortical activity and tremors in patients with essential tremor

AuthorsIbáñez Pereda, Jaime CSIC ORCID ; González de la Aleja, Jesús; Gallego, Juan Álvaro CSIC ORCID CVN; Romero, Juan P.; Saíz-Díaz, Rosana A.; Benito-León, Julián; Rocón, Eduardo CSIC ORCID
KeywordsEssential tremor
Alprazolam (benzodiazepine)
Cortical activity
Issue Date29-Sep-2014
CitationPLoS ONE 9(3):e93159 (2014)
AbstractEssential tremor (ET) is characterised by postural and action tremors with a frequency of 4–12 Hz. Previous studies suggest that the tremor activity originates in the cerebello-thalamocortical pathways. Alprazolam is a short-acting benzodiazepine that attenuates tremors in ET. The mechanisms that mediate the therapeutic action of alprazolam are unknown; however, in healthy subjects, benzodiazepines increase cortical beta activity. In this study, we investigated the effect of alprazolam both on beta and tremor-related cortical activity and on alterations in tremor presentation in ET patients. Therefore, we characterised the dynamics of tremor and cortical activity in ET patients after alprazolam intake.
Publisher version (URL)10.1371/journal.pone.0093159
Appears in Collections:(CAR) Artículos
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