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Título

Effects of Alprazolam on cortical activity and tremors in patients with essential tremor

Autor Ibáñez Pereda, Jaime ; González de la Aleja, Jesús; Gallego, Juan Álvaro ; Romero, Juan P.; Saíz-Díaz, Rosana A.; Benito-León, Julián; Rocón, Eduardo
Palabras clave Essential tremor
Alprazolam (benzodiazepine)
Cortical activity
Fecha de publicación 29-sep-2014
Citación PLoS ONE 9(3):e93159 (2014)
ResumenEssential tremor (ET) is characterised by postural and action tremors with a frequency of 4–12 Hz. Previous studies suggest that the tremor activity originates in the cerebello-thalamocortical pathways. Alprazolam is a short-acting benzodiazepine that attenuates tremors in ET. The mechanisms that mediate the therapeutic action of alprazolam are unknown; however, in healthy subjects, benzodiazepines increase cortical beta activity. In this study, we investigated the effect of alprazolam both on beta and tremor-related cortical activity and on alterations in tremor presentation in ET patients. Therefore, we characterised the dynamics of tremor and cortical activity in ET patients after alprazolam intake.
Versión del editor10.1371/journal.pone.0093159
URI http://hdl.handle.net/10261/102634
DOI10.1371/journal.pone.0093159
E-ISSN1932-6203
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