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Title

Design and preparation of single-chain nanocarriers mimicking disordered proteins for combined delivery of dermal bioactive cargos

AuthorsSánchez-Sánchez, Ana; Akbari, Somayeh; Moreno Segurado, Ángel J. ; Lo Verso, Federica; Arbe, Arantxa ; Colmenero de León, Juan ; Pomposo, José A.
KeywordsNanomedicine
Drug delivery
Self-assembly
Nanoparticles
Nanocarriers
Issue Date2013
PublisherWiley-VCH
CitationMacromolecular Rapid Communications 34(21): 1681-1686 (2013)
AbstractInspired by the multifunctionality of vitamin D-binding protein and the multiple transient-binding behavior of some intrinsically disordered proteins (IDPs), a polymeric platform is designed, prepared, and characterized for combined delivery of dermal protective and anticancer bioactive cargos on the basis of artificial single-chain nano-objects mimicking IDPs. For the first time ever, simultaneous delivery of folic acid or vitamin B9, and hinokitiol, a relevant natural bioactive compound that exhibits anticancer activity against human malignant melanoma cells, from these multidirectionally self-assembled unimolecular nanocarriers is illustrated.
Publisher version (URL)http://dx.doi.org/10.1002/marc.201300562
URIhttp://hdl.handle.net/10261/102311
DOI10.1002/marc.201300562
Identifiersdoi: 10.1002/marc.201300562
issn: 1022-1336
e-issn: 1521-3927
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