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Título: | Design and preparation of single-chain nanocarriers mimicking disordered proteins for combined delivery of dermal bioactive cargos |
Autor: | Sánchez-Sánchez, Ana CSIC; Akbari, Somayeh; Moreno Segurado, Ángel J. CSIC ORCID ; Lo Verso, Federica CSIC ORCID; Arbe, Arantxa CSIC ORCID; Colmenero de León, Juan CSIC ORCID; Pomposo, José A. CSIC ORCID | Palabras clave: | Nanomedicine Drug delivery Self-assembly Nanoparticles Nanocarriers |
Fecha de publicación: | 2013 | Editor: | Wiley-VCH | Citación: | Macromolecular Rapid Communications 34(21): 1681-1686 (2013) | Resumen: | Inspired by the multifunctionality of vitamin D-binding protein and the multiple transient-binding behavior of some intrinsically disordered proteins (IDPs), a polymeric platform is designed, prepared, and characterized for combined delivery of dermal protective and anticancer bioactive cargos on the basis of artificial single-chain nano-objects mimicking IDPs. For the first time ever, simultaneous delivery of folic acid or vitamin B9, and hinokitiol, a relevant natural bioactive compound that exhibits anticancer activity against human malignant melanoma cells, from these multidirectionally self-assembled unimolecular nanocarriers is illustrated. | Versión del editor: | http://dx.doi.org/10.1002/marc.201300562 | URI: | http://hdl.handle.net/10261/102311 | DOI: | 10.1002/marc.201300562 | Identificadores: | doi: 10.1002/marc.201300562 issn: 1022-1336 e-issn: 1521-3927 |
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