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Título

Different stressors induce differential responses of the CRH-stress system in the gilthead sea bream (Sparus aurata)

Autor Martos-Sitcha, Juan Antonio ; Wunderink, Yvette S.; Straatjes, Justin; Skrzynska, Arleta K.; Mancera, Juan Miguel; Martínez-Rodríguez, Gonzalo
Palabras clave Cortisol
Sparus aurata
Food deprivation
CRH
CRH-binding protein
Environmental salinity
Fecha de publicación nov-2014
EditorElsevier
Citación Comparative Biochemistry and Physiology - A - Molecular and Integrative Physiology 177: 49-61 (2014)
ResumenThe hypothalamus-pituitary-interrenal (HPI) axis, involved in the regulation of the neuroendocrine stress responses, presents important players such as corticotropin-releasing hormone (CRH, generally considered as the initiator of this pathway) and CRH-binding protein (CRH-BP, considered as an antagonist of CRH function). CRH and CRH-BP full-length cDNA sequences were obtained from Sparus aurata by screening a brain cDNA library, and their phylogenetic analysis as well as their roles during acute and chronic stress responses were assessed. mRNA expression levels and plasma cortisol concentrations were measured by RT qPCR and ELISA, respectively, in S. aurata juveniles submitted to: i) different environmental salinities in a short-time course response; and ii) food deprivation during 21. days. In addition, osmoregulatory and metabolic parameters in plasma corroborated a clear reorganization depending on the stress source/period. Salinity transfer induced stress as indicated by enhanced plasma cortisol levels, as well as by up-regulated CRH and down-regulated CRH-BP expression values. On the other hand, food deprivation did not affect both expression levels, although plasma cortisol concentrations were enhanced. These results suggest that different stressors are handled through different stress pathways in S. aurata. © 2014 Elsevier Inc.
Versión del editorhttp://dx.doi.org/10.1016/j.cbpa.2014.07.021
URI http://hdl.handle.net/10261/102218
DOI10.1016/j.cbpa.2014.07.021
Identificadoresdoi: 10.1016/j.cbpa.2014.07.021
issn: 1531-4332
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