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"Michael" nanocarriers mimicking transient-binding disordered proteins

AutorSánchez-Sánchez, Ana; Akbari, Somayeh; Etxeberria, Agustín; Arbe, Arantxa ; Gasser, Urs; Moreno Segurado, Ángel J. ; Colmenero de León, Juan ; Pomposo, José A.
Fecha de publicación2013
EditorAmerican Chemical Society
CitaciónACS Macro Letters 2(6): 491-495 (2013)
ResumenWe report herein a very efficient synthesis strategy for the construction of artificial transient-binding protein-mimic nano-objects. Michael addition-mediated multidirectional self-assembly of individual polymeric chains at r.t. leads to >Michael> nanocarriers that in solution resemble disordered multidomain proteins, as revealed by a combination of small angle neutron scattering measurements and coarse-grained molecular dynamics simulation results, whereas in the dry state adopt a collapsed, globular morphology, as observed by transmission electron microscopy. This extended-to-compact morphology transition taking place upon solvent removal is of paramount importance, among other applications, for the construction of efficient biosensors based on immobilized protein-mimic nano-objects and for the development of transient vitamin-binding systems. As a proof of concept, we show the controlled delivery of vitamin B9 from these novel transient-binding nanocarriers. © 2013 American Chemical Society.
Versión del editorhttp://dx.doi.org/10.1021/mz400173c
URIhttp://hdl.handle.net/10261/102115
DOI10.1021/mz400173c
Identificadoresdoi: 10.1021/mz400173c
e-issn: 2161-1653
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