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Título: | "Michael" nanocarriers mimicking transient-binding disordered proteins |
Autor: | Sánchez-Sánchez, Ana CSIC; Akbari, Somayeh; Etxeberria, Agustín; Arbe, Arantxa CSIC ORCID; Gasser, Urs; Moreno Segurado, Ángel J. CSIC ORCID ; Colmenero de León, Juan CSIC ORCID; Pomposo, José A. CSIC ORCID | Fecha de publicación: | 2013 | Editor: | American Chemical Society | Citación: | ACS Macro Letters 2(6): 491-495 (2013) | Resumen: | We report herein a very efficient synthesis strategy for the construction of artificial transient-binding protein-mimic nano-objects. Michael addition-mediated multidirectional self-assembly of individual polymeric chains at r.t. leads to >Michael> nanocarriers that in solution resemble disordered multidomain proteins, as revealed by a combination of small angle neutron scattering measurements and coarse-grained molecular dynamics simulation results, whereas in the dry state adopt a collapsed, globular morphology, as observed by transmission electron microscopy. This extended-to-compact morphology transition taking place upon solvent removal is of paramount importance, among other applications, for the construction of efficient biosensors based on immobilized protein-mimic nano-objects and for the development of transient vitamin-binding systems. As a proof of concept, we show the controlled delivery of vitamin B9 from these novel transient-binding nanocarriers. © 2013 American Chemical Society. | Versión del editor: | http://dx.doi.org/10.1021/mz400173c | URI: | http://hdl.handle.net/10261/102115 | DOI: | 10.1021/mz400173c | Identificadores: | doi: 10.1021/mz400173c e-issn: 2161-1653 |
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