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Title

Endowing single-chain polymer nanoparticles with enzyme-mimetic activity

AuthorsPérez-Baena, Irma ; Barroso-Bujans, Fabienne ; Gasser, Urs; Arbe, Arantxa ; Moreno Segurado, Ángel J. ; Colmenero de León, Juan ; Pomposo, José A.
Issue Date2013
PublisherAmerican Chemical Society
CitationACS Macro Letters 2(9): 775-779 (2013)
AbstractThe development of simple, efficient, and robust strategies affording the facile construction of biomimetic organocatalytic nano-objects is currently a subject of great interest. Herein, a new pathway to artificial organocatalysts based on partially collapsed individual soft nano-objects displaying useful and diverse biomimetic catalytic functions is reported. Single-chain polymer nanoparticles endowed with enzyme-mimetic activity synthesized following this new route display (i) a relatively extended morphology under good solvent conditions, as revealed by small angle neutron scattering and coarse-grained molecular dynamics simulation results, (ii) multiple, compartmentalized, and accessible catalytic sites in which borane catalytic units are retained via B···O interactions, and (iii) unprecedented reductase and polymerase enzyme-mimetic properties. © 2013 American Chemical Society.
Publisher version (URL)http://dx.doi.org/10.1021/mz4003744
URIhttp://hdl.handle.net/10261/102114
DOI10.1021/mz4003744
Identifiersdoi: 10.1021/mz4003744
e-issn: 2161-1653
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