English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/102000
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

Title

Mechano heterocyclic chemistry: Grinding and Ball Mills

AuthorsClaramunt, Rosa M.; Lopez, Concepción; Sanz, Dionisia; Elguero, José
Issue Date2014
PublisherElsevier
CitationAdvances in Heterocyclic Chemistry 112: 117- 143 (2014)
AbstractThis review covers till 2013 the main publications dealing with the use of mechanochemistry in heterocyclic chemistry. Physical aspects, like polymorphism and cocrystals, physicochemical problems, like tautomerism and desmotropy, and pure chemical ones, like synthesis and reactivity, are discussed. The review puts special emphasis on active pharmaceutical ingredients and, in general, on biological aspects. It will become clear that the technique has the advantages of time, simplicity, cost, and lower waste. Moreover, some complex structures that are difficult to prepare in solution, can be easily obtained by using simple, solventless grinding. The conclusion of this survey is that mechanochemistry will become another green method as important as microwave ovens in chemistry, although much exciting work remains to be done, both experimental and theoretically.
URIhttp://hdl.handle.net/10261/102000
DOI10.1016/B978-0-12-800171-4.00003-2
Identifiersdoi: 10.1016/B978-0-12-800171-4.00003-2
issn: 0065-2725
Appears in Collections:(IQM) Artículos
Files in This Item:
File Description SizeFormat 
accesoRestringido.pdf15,38 kBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.