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Título

Orchestration of floral initiation by APETALA1

Autor Kaufmann, Kerstin; Ferrier, Thilia; Serrano Mislata, Antonio; Madueño, Francisco; Riechmann, José Luis
Fecha de publicación 2-abr-2010
EditorAmerican Association for the Advancement of Science
Citación Science 328(5974): 85-89 (2010)
ResumenThe MADS-domain transcription factor APETALAl (AP1) is a key regulator of Arabidopsis flower development. To understand the molecular mechanisms underlying AP1 function, we identified its target genes during floral initiation using a combination of gene expression profiling and genome-wide binding studies. Many of its targets encode transcriptional regulators, including known floral repressors. The latter genes are down-regulated by AP1, suggesting that it initiates floral development by abrogating the inhibitory effects of these genes. Although AP1 acts predominantly as a transcriptional repressor during the earliest stages of flower development, at more advanced stages it also activates regulatory genes required for floral organ formation, indicating a dynamic mode of action. Our results further imply that AP1 orchestrates floral initiation by integrating growth, patterning, and hormonal pathways.
Descripción Kaufmann, Kerstin et al.
URI http://hdl.handle.net/10261/101903
DOI10.1126/science.1185244
Identificadoresdoi: 10.1126/science.1185244
issn: 0036-8075
e-issn: 1095-9203
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