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Enantioselective synthesis of PPAR (peroxisome proliferator-activated receptors) agonists and antagonists

AuthorsGoya, Pilar ; Pérez-Fernández, Ruth ; González-Muñiz, Rosario ; Elguero, José
KeywordsEvans' chiral auxiliary
Asymmetric hydrogenation
Chiral HPLC
Chiral salts
Nantioselective separation
Enantioselective synthesis
Issue Date2014
PublisherBentham Science Publishers
CitationCurrent Topics in Medicinal Chemistry 14: 1283-1293 (2014)
AbstractThis review deals with stereoselective issues in PPAR ligands some of which are in clinical use for treating certain metabolic disorders. After a short introduction of these nuclear receptor and their agonists, some cases of enantiose-lective separations are reported. The main part concerns stereoselective synthesis first starting with asymmetric synthesis from chiral precursors followed by what we refer to as >true> enantioselective methods. Some examples are discussed in detail for each particular heading.
Identifiersdoi: 10.2174/1568026614666140423112822
issn: 1568-0266
e-issn: 1873-4294
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