English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/101659
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE
Exportar a otros formatos:

Title

Simvastatin prevents the induction of interleukin-6 gene expression by titanium particles in human osteoblastic cells

AuthorsVallés, Gema; Pérez, Concepción; Boré, Alba; Martín-Saavedra, Francisco; Saldaña, Laura; Vilaboa, Nuria
KeywordsOsteolysis
Wear particles
Simvastatin
Osteoblast
IL-6
Issue Date2013
PublisherElsevier
CitationActa Biomaterialia 9: 4916- 4925 (2013)
AbstractOne of the most important complications of total joint arthroplasty is failure associated with periprosthetic osteolysis, a process mainly initiated by the biological response to wear-derived products from the biomaterials in service. The inflammatory mediator interleukin-6 (IL-6) plays a key role in the establishment and progression of aseptic loosening. Metal particles specifically up-regulate IL-6 production in bone-forming cells and implant-bone interfacial tissues. The use of statins has been recently associated with a significantly reduced risk of revision in patients that undergo total hip arthroplasty. We hypothesized that simvastatin (Simv) could modulate the osteoblastic response to titanium particles (Ti) by attenuating the production of IL-6. Pre-treatment of human osteoblastic cells with Simv down-regulated Ti particle-induced IL-6 gene expression at mRNA and protein levels. The effect of Simv on Ti-induced IL-6 production in osteoblastic cells could not be explained by inhibition of the internalization of metal particles. The mechanism involved in this down-regulation is based in the inhibition of the HMG-CoA/GGPP/RhoA/ROCK pathway, independently of Simv effects in the cholesterol synthesis. The cytokine-lowering property of Simv has been observed in Saos-2 cells and human primary osteoblasts (hOBs) exposed to Ti particles, and was further enhanced when hOBs were co-cultured with macrophages.
URIhttp://hdl.handle.net/10261/101659
DOIhttp://dx.doi.org/10.1016/j.actbio.2012.08.027
Identifiersdoi: 10.1016/j.actbio.2012.08.027
issn: 1742-7061
e-issn: 1878-7568
Appears in Collections:(IQM) Artículos
Files in This Item:
File Description SizeFormat 
accesoRestringido.pdf15,38 kBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.