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Physiological response to persistent organic pollutants in fish from mountain lakes: analysis of CYP1A gene expression in natural populations of Salmo trutta

AutorQuirós, Laia ; Jarque, Sergio; Reinhard, Lackner; Fernández Ramón, M. Pilar; Grimalt, Joan O.; Piña, Benjamín
Palabras claveOrganic pollutants
Mountain lakes
Cyp1A Gene expression
Specific pathologies
Fecha de publicación15-jun-2007
EditorAmerican Chemical Society
CitaciónEnvironmental Science & Technology 41(14): 5154-5160 (2007)
ResumenCytochrome p450 1A (CYP1A) gene expression in fish liver increases upon exposure to a variety of chemical compounds, including organochlorine compounds (OCs) and polycyclic aromatic hydrocarbons (PAHs). To use this physiological response as a marker of environmental impact, we developed and validated a set of primers to quantify CYP1A expression by qRT-PCR in the brown trout, Salmo trutta. These primers were used to explore the natural variability of CYP1A expression in 8 isolated populations (65 samples) from European remote lakes, in a geographical distribution encompassing the Tyrolean Alps, Pyrenees, Rila, Tatras, and Norwegian and Scottish mountains. CYP1A expression values varied more than 2 orders of magnitude among samples, with strong variations within each population. CYP1A expression values were significantly elevated in Tatras and Pyrenees fish populations, whereas the lowest median values were found in populations from the Tyrolean Alps and Rila. These values correlated with the content of different environmentally relevant pollutants in the sediments of the lakes harboring each fish population, particularly with HCB and 4,4'-DDE contents. To our knowledge, this works represents a first report of a physiological response linked to persistent organic pollutants in fish from mountain lakes.
Descripción7 pages, 3 figures.-- PMID: 17711238 [PubMed].-- Printed version published on Jul 15, 2007.
Versión del editorhttp://dx.doi.org/10.1021/es070455p
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