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http://hdl.handle.net/10261/101394
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dc.contributor.author | Hernández-Hernández, Oswaldo | - |
dc.contributor.author | Marín-Manzano, M. Carmen | - |
dc.contributor.author | Rubio, Luis A. | - |
dc.contributor.author | Moreno, F. Javier | - |
dc.contributor.author | Sanz, M. Luz | - |
dc.contributor.author | Clemente, Alfonso | - |
dc.date.accessioned | 2014-08-29T07:35:30Z | - |
dc.date.available | 2014-08-29T07:35:30Z | - |
dc.date.issued | 2012 | - |
dc.identifier | doi: 10.3945/jn.111.155762 | - |
dc.identifier | issn: 0022-3166 | - |
dc.identifier | e-issn: 1541-6100 | - |
dc.identifier.citation | Journal of Nutrition 142(7): 1232-1239 (2012) | - |
dc.identifier.uri | http://hdl.handle.net/10261/101394 | - |
dc.description.abstract | A detailed study was performed to compare the in vivo ileal digestibility and modulatory effects in fecal microbiota of novel galacto-oligosaccharides (GOS) derived from lactulose [GOS-Lu; degree of polymerization (DP) ≥2, 14.0% trisaccharides] and commercial GOS derived from lactose (GOS-La; DP ≥3, 35.1% trisaccharides) in growing rats (5wk old). Rats were fed either a control diet or diets containing 1% (wt:wt) of GOS-Lu or GOS-La for 14 d. Quantitative analysis of carbohydrates from dietary and ileal samples demonstrated that the trisaccharide fraction of GOS-Lu was significantly more resistant to gut digestion than that from GOS-La, as indicated by their ileal digestibility rates of 12.5 6 2.6% and 52.9 ± 2.7%, respectively, whereas the disaccharide fraction of GOS-Lu was fully resistant to the extreme environment of the upper digestive tract. The low ileal digestibility of GOS-Lu was due to the great resistance of galactosyl-fructoses to mammalian digestive enzymes, highlighting the key role played by the monomer type and linkage involved in the oligosaccharide chain. The partial digestion of GOS-La trisaccharides showed that glycosidic linkages (1→6) and (1→2) between galactose and glucose monomers were significantly more resistant to in vivo gastrointestinal digestion than the linkage (1→4) between galactose units. The absence of GOS-La and GOS-Lu digestion-resistant oligosaccharides in fecal samples indicated that they were readily fermented within the large intestine, enabling both types of GOS to have a potential prebiotic function. Indeed, compared with controls, the GOS-Lu group had significantly more bifidobacteria in fecal samples after 14 d of treatment. The number of Eubacterium rectale also was greater in the GOS-Lu and GOS-La groups than in controls. These novel data support a direct relationship between patterns of resistance to digestion and prebiotic properties of GOS. © 2012 American Society for Nutrition. | - |
dc.description.sponsorship | Supported by the Spanish Council for Scientific Research (PIF-SIALOBIOTIC 200870F010-1, -2, and -3), an ERDF-cofinanced grant from Junta de Comunidades de Castilla-La Mancha (POII10-0178-4685), and MICINN (AGL2011-27884). O.H. thanks to Consejo Superior de Investigaciones Científicas for a JAE-PreDoc PhD grant. | - |
dc.publisher | American Society for Nutritional Sciences | - |
dc.rights | closedAccess | - |
dc.title | Monomer and linkage type of galacto-oligosaccharides affect their resistance to ileal digestion and prebiotic properties in rats | - |
dc.type | artículo | - |
dc.identifier.doi | 10.3945/jn.111.155762 | - |
dc.date.updated | 2014-08-29T07:35:30Z | - |
dc.description.version | Peer Reviewed | - |
dc.language.rfc3066 | eng | - |
dc.contributor.funder | Consejo Superior de Investigaciones Científicas (España) | - |
dc.contributor.funder | Junta de Comunidades de Castilla-La Mancha | - |
dc.contributor.funder | Ministerio de Ciencia e Innovación (España) | - |
dc.contributor.funder | European Commission | - |
dc.identifier.funder | http://dx.doi.org/10.13039/501100003339 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100004837 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100000780 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100011698 | es_ES |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairetype | artículo | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | No Fulltext | - |
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