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In vitro fermentation of lactulose-derived oligosaccharides by mixed fecal microbiota

AuthorsCardelle-Cobas, Alejandra ; Olano, Agustín ; Corzo, Nieves ; Villamiel, Mar ; Collins, Michelle; Kolida, Sofía; Rastall, Robert A.
Short-chain fatty acids
Gut microbiota
Issue Date2012
PublisherAmerican Chemical Society
CitationJournal of Agricultural and Food Chemistry 60(8): 2024-2032 (2012)
AbstractFermentation properties of oligosaccharides derived from lactulose (OsLu) and lactose (GOS) have been assessed in pH-controlled anaerobic batch cultures using lactulose and Vivinal-GOS as reference carbohydrates. Changes in gut bacterial populations and their metabolic activities were monitored over 24 h by fluorescent in situ hybridization (FISH) and by measurement of short-chain fatty acid (SCFA) production. Lactulose-derived oligosaccharides were selectively fermented by Bifidobacterium and lactic acid bacterial populations producing higher SCFA concentrations compared to GOS. The highest total SCFA production was from Vivinal-GOS > lactulose > OsLu > GOS. Longer incubation periods produced a selective fermentation of OsLu when they were used as a carbon source reaching the highest selective index scores. The new oligosaccharides may constitute a good alternative to lactulose, and they could belong to a new generation of prebiotics to be used as a functional ingredient for improving the composition of gut microflora. © 2012 American Chemical Society.
Identifiersdoi: 10.1021/jf203622d
issn: 0021-8561
e-issn: 1520-5118
Appears in Collections:(CIAL) Artículos
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