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Effect of Flavan-3-ols on the adhesion of potential probiotic lactobacilli to intestinal cells

AuthorsBustos, Irene ; García-Cayuela, Tomás ; Hernández-Ledesma, Blanca ; Peláez, Carmen ; Requena, Teresa ; Martínez-Cuesta, M. Carmen
Issue Date2012
PublisherAmerican Chemical Society
CitationJournal of Agricultural and Food Chemistry 60(36): 9082-9088 (2012)
AbstractThe effect of dietary flavan-3-ols on the adhesion of potential probiotic lactobacilli strains to intestinal cells was unraveled. The inhibitory activity of these compounds on intestinal cells was highlighted. The cytotoxic effect was shown to depend on both the compound¿s chemical structure (galloylation and polymerization) and degree of differentiation of intestinal cells. The effect of flavan-3-ols on bacteria adhesion differed greatly between compounds, strains, and intestinal cells. All flavan-3-ols inhibited significantly Lactobacillus acidophilus LA-5 and Lactobacillus plantarum IFPL379 adhesion except epigallocatechin gallate, which enhanced L. acidophilus LA-5 adhesion to Caco-2. Procyanidins B1 and B2 increased remarkably the adhesion of Lactobacillus casei LC115 to HT-29 cells, whereas epigallocatechin increased L. casei LC115 adhesion to Caco-2. These data showed the potential of flavan-3-ols to alter gut microecology by modifying adhesion of lactobacilli strains to intestinal cells.
Identifiersdoi: 10.1021/jf301133g
issn: 0021-8561
e-issn: 1520-5118
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