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Título

Antiviral compounds obtained from microalgae commonly used as carotenoid sources

Autor Santoyo, Susana ; Jaime, Laura ; Plaza, Merichel ; Herrero, Miguel ; Rodríguez-Meizoso, Irene; Ibáñez, Elena ; Reglero, Guillermo
Palabras clave Antiviral activity
Microalgae
Dunaliella salina
Haematococcus pluvialis
Pressurized liquid extraction
Fecha de publicación 2012
EditorSpringer
Citación Journal of Applied Phycology 24(4): 731-741 (2012)
ResumenPressurized liquid extraction (PLE), an environmentally friendly technique, has been used to obtain antiviral compounds from microalgae commonly used as carotenoid sources: Haematococcus pluvialis and Dunaliella salina. The antiviral properties of PLE extracts (hexane, ethanol and water) were evaluated against herpes simplex virus type 1 (HSV-1) at different stages during viral infection. Pretreatment of Vero cells with 75 μg mL -1 of H. pluvialis ethanol extract inhibited virus infection by approximately 85%, whereas the same concentration of water and hexane extracts reduced the virus infectivity 75% and 50%, respectively. D. salina extracts were less effective than H. pluvialis extracts and presented a different behaviour since water and ethanol extracts produced a similar virus inhibition (65%). Moreover, H. pluvialis ethanol extract was also the most effective against HSV-1 intracellular replication. The antiviral activity of water PLE extracts was found to correlate with polysaccharides since the polysaccharide-rich fraction isolated from these extracts showed higher antiviral activity than the original water extracts. A gas chromatography-mass spectrometry (GC-MS) characterization of the H. pluvialis ethanol extract showed the antiviral activity of this extract could be partially related with the presence of short-chain fatty acids, although other compounds could be involved in this activity; meanwhile, in the case of D. salina ethanol extract other compounds seemed to be implied, such as: β-ionone, neophytadiene, phytol, palmitic acid and α-linolenic acid. The results demonstrate the use of PLE allows obtaining antiviral compounds from microalgae used as carotenoids sources, which gives the microalgae biomass an added value. © 2011 Springer Science+Business Media B.V.
Versión del editorhttp://dx.doi.org/10.1007/s10811-011-9692-1
URI http://hdl.handle.net/10261/101235
DOI10.1007/s10811-011-9692-1
Identificadoresdoi: 10.1007/s10811-011-9692-1
issn: 0921-8971
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