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Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/101232
Título

LSM proteins provide accurate splicing and decay of selected transcripts to ensure normal arabidopsis development

AutorPerea-Resa, Carlos; Hernández-Verdeja, Tamara; López-Cobolloa, Rosa; Castellano, María del Mar; Salinas, Julio
Fecha de publicacióndic-2012
EditorAmerican Society of Plant Biologists
CitaciónThe Plant Cell, Vol. 24: 4930–4947
ResumenIn yeast and animals, Sm-like (LSM) proteins typically exist as heptameric complexes and are involved in different aspects of RNA metabolism. Eight LSM proteins, LSM1-8, are highly conserved and form two distinct heteroheptameric complexes, LSM1-7 and LSM2-8, that function in mRNA decay and splicing, respectively. A search of the Arabidopsis thaliana genome identifies eleven genes encoding proteins related to the eight conserved LSMs, the genes encoding the putative LSM1, LSM3 and LSM6 proteins being duplicated. Here, we report the molecular and functional characterization of the Arabidopsis LSM gene family. Our results show that the eleven LSM genes are active and encode proteins that are also organized in two different heptameric complexes. The complex LSM1-7 is cytoplasmic and is involved in P-body formation and mRNA decay by promoting decapping. The complex LSM2-8 is nuclear and is required for pre-mRNA splicing through U6 snRNA stabilization. More important, our results also reveal that these complexes are essential for the correct turnover and splicing of selected developmental-related mRNAs, and for the normal development of Arabidopsis. We propose that LSMs play a critical role in Arabidopsis development by ensuring the appropriate developmental-related gene expression through the control of mRNA splicing and decay.
Descripción57 p.-9 fig.-10 fig. supl. Este artículo forma parte de la tesis de Tamara Hernández-Verdeja, que se puede consultar en : http://digital.csic.es/handle/10261/109043
Versión del editorhttp://dx.doi.org/10.1105/tpc.112.103697
URIhttp://hdl.handle.net/10261/101232
DOI10.1105/tpc.112.103697
ISSN1040-4651
E-ISSN1532-298X
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