English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/101069
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE
Exportar a otros formatos:


Alternative splicing variants of proinsulin mRNA and the effects of excess proinsulin on cardiac morphogenesis

AuthorsMartínez-Campos, Enrique; Hernández-SanMiguel, Esther; López-Sánchez, Carmen; Pablo, Flora de ; Hernández-Sánchez, Catalina
Insulin gene
Alternative splicing
Intron retention
Cardiac malformation
Issue Date6-Jun-2013
CitationFEBS Letters 587 (2013) 2272–2277
AbstractAlternative forms of proinsulin mRNA with differential translational capacities and unknown significance are expressed in several developing tissues and in the adult pancreas. In the chick embryo developing heart, we observed low expression of the translationally active transcript of embryonic proinsulin (Pro1B), and predominant expression of the intron 1-unspliced variant, translationally inactive. In the embryonic mouse heart, intron 1-unspliced isoform appeared after E12.5. This tight regulation is required for normal development, since overexpression of Pro1B resulted in abnormal cardiac morphogenesis in 40% of chick embryos, and was accompanied by changes in gene expression of Amhc1and Vmhc1.
Description31 p.-5 fig.-mat.sup.
Publisher version (URL)http://dx.doi.org/10.1016/j.febslet.2013.05.060
Appears in Collections:(CIB) Artículos
Files in This Item:
File Description SizeFormat 
Martínez-Campos et al_2013_FEBS Letters 587(14)2272-2277.pdf7,34 MBAdobe PDFThumbnail
Show full item record
Review this work

Related articles:

WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.