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Emerging regulation and functions of autophagy

AuthorsBoya, Patricia ; Reggiori, Fulvio; Codogno, Patrice
Issue DateJul-2013
PublisherNature Publishing Group
CitationNature Celll Biology 15 (7 ) 713-720 (2013)
AbstractAutophagy is crucial to maintain cell, tissue and organism homeostasis through degradation. This review will emphasize the relevance of its regulation by describing the recent advances in our understanding of the complex post-translational modulation of the Atg (AuTophaGy-related)proteins and the emerging notion of the cell type-specific regulation of autophagy. New data have also revealed unexpected roles of this pathway and that the ATG genes carry out autophagyunrelated functions thus projecting the autophagy research field beyond the boundaries drawn by the simplistic view of a process exclusively dedicated to the turnover of cellular components. This piece is also discussing these new discoveries to highlight the novel frontiers lying ahead.
Description27 p.-3 fig.-1 tab.El postprint depositado contiene un título diferente al del pdf editorial ("Autophagy: New emerging functions and concepts")
Publisher version (URL)http://dx.doi.org/10.1038/ncb2788
Appears in Collections:(CIB) Artículos
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