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Malignant giant-cell tumor of bone with lymph node involvement in a cat

AuthorsAkkoc, A.; Sönmez, G.; Yanik, K.; Alasonyalilar Demirer, Aylin; Gül, N.; Ferreras, Mª del Carmen
KeywordsGiant-cell tumor of bone
Lymph node involvement
Issue Date2011
PublisherScientific and Technological Research Council of Turkey
CitationTurkish Journal of Veterinary and Animal Sciences 35: 369- 373 (2011)
Abstract: Th e present study describes giant-cell tumor of bone (GCToB) with lymph node involvement in a 5-year-old crossbred cat. Th e animal was referred to the surgery clinic with progressive subcutaneous swelling in the left proximal femoral region, severe lameness, constipation, and dysuria. A moderately fi rm, subcutaneous, palpable mass, 9 cm in diameter, was observed, and biopsy samples were taken. Histopathologically, the mass was constituted by ovoid-shaped mononuclear cells intermixed with many multinucleated giant cells (MGC). Immunohistochemically, the giant cells were positively stained with antivimentin, and the same cells were negative for antidesmin and anti-S100 staining. Tartrate-resistant acid phosphatase (TRAP) activity in tumor cells was evaluated and the tumor was diagnosed as malignant GCToB; the cat was euthanized. Macroscopically, while the regional lymph nodes were intact, giant cells were found in the left popliteal lymph node during microscopy. Although a few cases of GCToB have been reported in cats, the case herein displays, for the fi rst time, evidence of lymph node involvement during the process of metastasis.
Publisher version (URL)http://dx.doi.org/:10.3906/vet-1011-573
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