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Title

Nitric oxide mediates the antihypertensive and vascular relaxing effects of a soluble cocoa fiber product in spontaneously hypertensive rats

AuthorsFernández-Vallinas, Sandra; López-Carreras, Noemi; Miguel, Marta ; Aleixandre, Amaya
KeywordsHypertension
Endothelium
Cocoa
Nitric oxide
Spontaneously hypertensive rats
Fiber
Issue Date2013
PublisherElsevier
CitationNitric Oxide 29: 1-3 (2013)
AbstractThe involvement of endothelial-relaxing factors on the vascular and antihypertensive effects of a cocoa fiber product (CFP) obtained from cocoa husks was studied. We carried out in vitro experiments with aorta rings from untreated spontaneously hypertensive rats (SHR) and in vivo experiments with SHR. CFP did not relax the endothelium denuded aorta rings and N W-nitro-l-arginine methyl ester (l-NAME) partially blocked the vascular relaxing and antihypertensive effects of CFP. Nevertheless, indomethacin did not modify these effects. Nitric oxide mediates therefore the antihypertensive and aorta relaxing effects of CFP in SHR. © 2013 Elsevier Inc. All rights reserved.
URIhttp://hdl.handle.net/10261/100155
DOI10.1016/j.niox.2012.10.006
Identifiersdoi: 10.1016/j.niox.2012.10.006
issn: 1089-8603
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