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Lack of PrP (sc) immunostaining in intracranial ectopic lymphoid follicles in a sheep with concomitant non-suppurative encephalitis and Nor98-like atypical scrapie: a case report

AuthorsVidal, E.; Tortosa, R.; Costa, C.; Benavides, Julio ; Francino, Olga ; Sánchez-Robert, E.; Pérez Pérez, Valentín ; Pumarola, M.
Atypical scrapie
Issue Date2008
CitationVeterinary Journal 177: 283- 288 (2008)
AbstractDuring active surveillance for transmissible spongiform encephalopathies (TSEs) in sheep, an initial reactor was detected using a rapid test on a brain sample. Immunohistochemistry confirmed an atypical TSE presentation that closely resembled the previously described Nor98 cases. Sequencing of the prnp gene confirmed the ARQ/AHQ genotype with the L141F mutation at codon 141 associated with this phenotype. The head, including the brain and cranial lymphoid tissues, was sampled and examined thoroughly. Non-purulent encephalitis, with ectopic lymphoid follicle formation within the brain, was diagnosed concomitant to the TSE. When scrapie-associated prion protein (PrPsc) deposition was studied by immunohistochemistry there was a noticeable lack of lymphotropism. The distribution of PrPsc in the brain differed considerably from that of classical scrapie cases. Astrogliosis and microgliosis were demonstrated by histochemical procedures.
Description6 páginas, 5 figuras.
Publisher version (URL)http://dx.doi.org/10.1016/j.tvjl.2007.04.014
Appears in Collections:(IGM) Artículos
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