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Metabolomics in Alzheimer's disease research

AutorIbáñez, Clara ; Simó, Carolina ; Cifuentes, Alejandro
Palabras claveMild cognitive impairment
Multivariate statistical analysis
Metabolomics
Biomarker
Alzheimer's disease
Fecha de publicación2013
EditorWiley-VCH
CitaciónELECTROPHORESIS 34(19): 2799-2811 (2013)
ResumenAlzheimer's disease (AD) is a neurodegenerative multifactorial disease whose cause is still unknown. The majority of AD biochemical markers currently available have been developed as an extension of targeted physiological studies on the basis of the >amyloid hypothesis.> The potential of metabolomics for the discovery of novel biomarkers and elucidation of new biochemical pathways modified in the progression of AD is highlighted in this review work. A variety of nontargeted metabolomic approaches for the discrimination between healthy subjects and AD patients are described. Moreover, the feasibility of metabolomics to predict progression to AD in individuals with mild cognitive impairment is also presented. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
URIhttp://hdl.handle.net/10261/100139
DOI10.1002/elps.201200694
Identificadoresdoi: 10.1002/elps.201200694
issn: 0173-0835
e-issn: 1522-2683
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