English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/100130
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:
Title

Histopathological classification of lesions associated with natural paratuberculosis infection in cattle

AuthorsGonzález, J.; Geijo, M. V.; García Pariente, C.; Verna, A.; Corpa, J. M.; Reyes, L. E.; Ferreras, Mª del Carmen ; Juste, R. A.; García Marín, Juan Francisco ; Pérez Pérez, Valentín
KeywordsGranuloma
Cattle
Bacterial infection
Johne’s disease
Iymphoid tissue
Paratuberculosis lesions
Mycobacterium avium subsp. paratuberculosis
Issue Date2005
PublisherElsevier
CitationJournal of Comparative Pathology 133: 184- 196 (2005)
AbstractParatuberculosis-associated lesions in 116 naturally infected adult cows, with or without clinical signs, were classified histopathologically. Tissue samples obtained focused on gut-associated lymphoid tissue. Lesions were divided into five categories. Focal lesions (n=68 cases), consisted of small granulomas in the ileal and jejunal lymph nodes or the ileocaecal lymphoid tissue. In the multifocal type (n=13 cases), small granulomas or scattered giant cells appeared in some intestinal villi, as well as in the lymph nodes. Diffuse multibacillary lesions (n=15 cases), associated with severe granulomatous enteritis affecting different intestinal locations and lymph nodes, were formed by macrophages containing large numbers of acid-fast bacilli. In diffuse lymphocytic lesions (n=3 cases), lymphocytes were the main inflammatory cells, with some macrophages or giant cells containing few if any mycobacteria. In diffuse intermediate forms (n=17 cases), the infiltrate was formed by abundant lymphocytes and macrophages, and mycobacteria were present to varying degrees related to the number of macrophages. Clinical signs and gross lesions were mainly associated with diffuse forms. Thickening of the intestinal wall, which was the most common macroscopical finding, was related to the degree of submucosal change. Mycobacterium avium subsp. paratuberculosis was identified by culture or PCR in all cows with diffuse lesions, and in 55.5 and 37% of those with multifocal or focal forms, respectively. The importance of sampling the ileal and caudal jejunal lymph nodes to find histological lesions of paratuberculosis in cattle is emphasized. (c) 2005 Elsevier Ltd. All rights reserved.
Description13 páginas, 8 figuras, 14 tablas.
Publisher version (URL)http://dx.doi.org/10.1016/j.jcpa.2005.04.007
URIhttp://hdl.handle.net/10261/100130
DOI10.1016/j.jcpa.2005.04.007
ISSN0021-9975
Appears in Collections:(IGM) Artículos
Files in This Item:
File Description SizeFormat 
accesoRestringido.pdf15,38 kBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.