English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/100128
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:


Giant cell tumour of bone in a cat with extraskeletal metastases: Pathological and immunohistochemical study

AuthorsFerreras, Mª del Carmen ; Fuertes, M. ; Pérez Pérez, Valentín ; Benavides, Julio ; García Pariente, C.; Reyes, L. E.; García Marín, Juan Francisco
Issue Date2005
PublisherChulalongkorn University
CitationThai Journal of Veterinary Medicine 52: 225- 229 (2005)
AbstractA case of giant cell tumour of bone (GCT(b)) in the lung and in a subcutaneous mass located in the right flank, with a probable primary origin in the mid-diaphysis of the right tibia, was described in a 8-year-old female cat. Numerous multinucleated giant cells were homogeneously distributed among a population of ovoid or spindle-shaped mononuclear cells. All of them were positive for vimentin suggesting a mesenchymal origin. Spindle-shaped tumour cells resemble fibroblastic cells, showing collagen fibres in their vicinity. Ovoid mononuclear cells are similar to macrophages, with a cytoplasm rich in electron-dense lysosomes. Multinucleated giant cells appear morphologically similar to osteoclasts. These findings are supported for the positive reaction to tartrate-resistant acid phosphatase (TRAP) and lysozyme, encountered only in ovoid and multinucleated giant cells. No immunoreactivity against human oestrogen receptors was observed in the nuclei of any neoplastic cells.
Description5 páginas, 9 figuras.
Publisher version (URL)http://dx.doi.org/10.1111/j.1439-0442.2005.00720.x
Appears in Collections:(IGM) Artículos
Files in This Item:
File Description SizeFormat 
accesoRestringido.pdf15,38 kBAdobe PDFThumbnail
Show full item record
Review this work

Related articles:

WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.