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Título

Giant cell tumour of bone in a cat with extraskeletal metastases: Pathological and immunohistochemical study

Autor Ferreras, Mª del Carmen ; Fuertes, M.; Pérez Pérez, Valentín ; Benavides, Julio ; García Pariente, C.; Reyes, L. E.; García Marín, Juan Francisco
Fecha de publicación 2005
EditorChulalongkorn University
Citación Thai Journal of Veterinary Medicine 52: 225- 229 (2005)
ResumenA case of giant cell tumour of bone (GCT(b)) in the lung and in a subcutaneous mass located in the right flank, with a probable primary origin in the mid-diaphysis of the right tibia, was described in a 8-year-old female cat. Numerous multinucleated giant cells were homogeneously distributed among a population of ovoid or spindle-shaped mononuclear cells. All of them were positive for vimentin suggesting a mesenchymal origin. Spindle-shaped tumour cells resemble fibroblastic cells, showing collagen fibres in their vicinity. Ovoid mononuclear cells are similar to macrophages, with a cytoplasm rich in electron-dense lysosomes. Multinucleated giant cells appear morphologically similar to osteoclasts. These findings are supported for the positive reaction to tartrate-resistant acid phosphatase (TRAP) and lysozyme, encountered only in ovoid and multinucleated giant cells. No immunoreactivity against human oestrogen receptors was observed in the nuclei of any neoplastic cells.
Descripción 5 páginas, 9 figuras.
Versión del editorhttp://dx.doi.org/10.1111/j.1439-0442.2005.00720.x
URI http://hdl.handle.net/10261/100128
DOI10.1111/j.1439-0442.2005.00720.x
ISSN0125-6491
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