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Galacto-oligosaccharides derived from lactulose exert a selective stimulation on the growth of Bifidobacterium animalis in the large intestine of growing rats

AuthorsMarín-Manzano, M. Carmen; Abecia, Leticia; Hernández-Hernández, Oswaldo ; Sanz, M. Luz ; Montilla, Antonia ; Olano, Agustín ; Rubio, Luis A. ; Moreno, F. Javier ; Clemente, Alfonso
Bifidobacterium animalis
Gut microbiota
Issue Date2013
PublisherAmerican Chemical Society
CitationJournal of Agricultural and Food Chemistry 61(31): 7560-7567 (2013)
AbstractThere is increasing interest in identifying novel dietary nondigestible carbohydrates capable of modulating the composition and/or metabolic activities of the gut microbiota. This work assessed the differential modulatory influence of novel galacto-oligosaccharides derived from lactulose (GOS-Lu) in comparison with commercial galacto-oligosaccharides derived from lactose (GOS-La) in gut microbiota of growing rats (5 weeks old). Rats were fed either a control diet or diets containing 1% (w/w) of GOS-Lu or GOS-La, and cecal and colonic contents were collected after 14 days of treatment. Compared to controls, GOS-Lu had significantly more bifidobacteria within the large intestine, showing a significant and selective increase of Bifidobacterium animalis in the cecum and colon; however, no significant differences in the number of bifidobacteria among GOS-Lu and GOS-La groups were observed. Both types of GOS significantly increased the number of the Eubacterium rectale/Clostridium coccoides group. These findings support a prebiotic role of galactosyl-fructoses in functional foods.
Identifiersdoi: 10.1021/jf402218z
issn: 0021-8561
e-issn: 1520-5118
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