DSpace Collection:http://hdl.handle.net/10261/9162024-03-29T12:38:03Z2024-03-29T12:38:03ZAminoglycoside antibioticsBastida, AgathaRevuelta, Juliahttp://hdl.handle.net/10261/3481652024-02-24T02:50:20Z2024-02-23T11:20:02ZTítulo: Aminoglycoside antibiotics
Autor: Bastida, Agatha; Revuelta, Julia
Resumen: Aminoglycosides are a family of natural, positively charged pseudo-oligosaccharides that have been widely used as antibiotics in the clinic. Nevertheless, their use has been restricted in recent decades for two reasons: their inherent toxicity and the development of self-resistance mechanisms in clinical isolates. To overcome these limitations, numerous studies have been conducted over the past decade aimed at understanding them at the molecular level. This knowledge has enabled the development of new aminoglycoside-based agents (second-generation aminoglycosides) to overcome the main limitations of the original antibiotics. This chapter reviews the major biological activities in which aminoglycosides are involved and their underlying mechanisms. It also covers the development of resistance, toxicity, and other aspects relevant to clinical use, such as pharmacology. Finally, some examples of new aminoglycosides produced on the basis of this knowledge are given.2024-02-23T11:20:02ZImmunodetection of proteins in high resolution separation systems.Frutos, Mercedes deMolina, ElenaPuerta, Angel de lahttp://hdl.handle.net/10261/3478162024-03-06T14:09:18Z2024-02-21T10:30:03ZTítulo: Immunodetection of proteins in high resolution separation systems.
Autor: Frutos, Mercedes de; Molina, Elena; Puerta, Angel de la2024-02-21T10:30:03ZAlkylation of alpha-Sulfur-Containing CarbanionsFernandez de de la Pradilla, RobertoViso, Almahttp://hdl.handle.net/10261/3461732024-02-09T02:48:49Z2024-02-08T10:23:51ZTítulo: Alkylation of alpha-Sulfur-Containing Carbanions
Autor: Fernandez de de la Pradilla, Roberto; Viso, Alma
Resumen: [EN] The alkylation of -sulfur stabilized carbanions is a valuable tool in continues to attract synthesis of natural and bioactive products as well as other complex molecules. This update comprises the alkylation of -sulfur-containing functionalities, sulfoxides, sulfones, sulfoximines, and geminal disulfur compounds with electrophiles such as alkyl halides and sulfonates, epoxides and aziridines, transition metal-catalyzed alkylations and arylations and the addition to C=C bonds, with particular enphasis on the applications in synthesis of natural products. The chapter covers the literature on this topic from 2011 to 2023.2024-02-08T10:23:51ZSynthesis of 1,3,4,6-Tetra-O-Acetyl-2-Azido-2-Deoxy-¿,ß-D-GalactopyranoseMann, EnriqueChiara, José LuisVerkhnyatskaya, Stellahttp://hdl.handle.net/10261/2720492022-06-09T09:57:42Z2022-06-09T09:40:03ZTítulo: Synthesis of 1,3,4,6-Tetra-O-Acetyl-2-Azido-2-Deoxy-¿,ß-D-Galactopyranose
Autor: Mann, Enrique; Chiara, José Luis; Verkhnyatskaya, Stella2022-06-09T09:40:03Z