2024-03-28T17:55:29Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/997502018-09-19T12:11:42Zcom_10261_31891com_10261_2col_10261_31892
Antioxidant activity and protective effects of peptide lunasin against oxidative stress in intestinal Caco-2 cells
García-Nebot, María José
Recio, Isidra
Hernández-Ledesma, Blanca
European Commission
Ministerio de Economía y Competitividad (España)
Consejo Superior de Investigaciones Científicas (España)
Intestinal health
Peptide lunasin
Antioxidant
Oxidative stress
Oxidative stress is one of the most critical factors implicated in many disorders of the gastrointestinal tract, such as inflammatory bowel diseases and colon cancer. Lunasin is a seed peptide known by its properties against cancer and cardiovascular diseases. The present study investigated the in vitro antioxidant activity of this peptide that demonstrated to be a potent scavenger of peroxyl and superoxide radicals. In addition, the protective role of lunasin on cell viability and antioxidant defenses of human Caco-2 cells challenged by hydrogen peroxide and tert-butylhydroperoxide was evaluated. This peptide remained partially intact during incubation time with cells, preventing of the oxidative damage induced by both chemical agents. The direct antioxidant action of lunasin (within the physiological range of concentrations) on enterocytes exposed to oxidizing species makes this peptide a promising agent to preserve the integrity of intestinal mucosa against oxidative damage related diseases. © 2013 Elsevier Ltd.
2014-07-14T07:52:29Z
2014-07-14T07:52:29Z
2014
2014-07-14T07:52:29Z
artículo
Food and Chemical Toxicology 65: 155-161 (2014)
http://hdl.handle.net/10261/99750
10.1016/j.fct.2013.12.021
http://dx.doi.org/10.13039/501100000780
http://dx.doi.org/10.13039/501100003329
http://dx.doi.org/10.13039/501100003339
eng
Preprint
http://dx.doi.org/10.1016/j.fct.2013.12.021
Sí
info:eu-repo/grantAgreement/EC/FP7/315349
openAccess
Elsevier