2024-03-28T12:04:17Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/981002021-05-24T09:24:59Zcom_10261_79com_10261_1col_10261_332
Neurogenic effects of β-amyloid in the choroid plexus epithelial cells in Alzheimer's disease
Bolós, Marta
Spuch, Carlos
Ordóñez-Gutiérrez, Lara
Wandosell, Francisco
Ferrer, Isidro
Carro, Eva
Alzheimer’s disease patients
Amyloid
Choroid plexus
Transgenic mice
Neurogenesis
β-amyloid (Aβ) can promote neurogenesis, both in vitro and in vivo, by inducing neural progenitor cells to differentiate into neurons. The choroid plexus in Alzheimer's disease (AD) is burdened with amyloid deposits and hosts neuronal progenitor cells. However, neurogenesis in this brain tissue is not firmly established. To investigate this issue further, we examined the effect of Aβ on the neuronal differentiation of choroid plexus epithelial cells in several experimental models of AD. Here we show that Aβ regulates neurogenesis in vitro in cultured choroid plexus epithelial cells as well as in vivo in the choroid plexus of APP/Ps1 mice. Treatment with oligomeric Aβ increased proliferation and differentiation of neuronal progenitor cells in cultured choroid plexus epithelial cells, but decreased survival of newly born neurons. These Aβ-induced neurogenic effects were also observed in choroid plexus of APP/PS1 mice, and detected also in autopsy tissue from AD patients. Analysis of signaling pathways revealed that pre-treating the choroid plexus epithelial cells with specific inhibitors of TyrK or MAPK diminished Aβ-induced neuronal proliferation. Taken together, our results support a role of Aβ in proliferation and differentiation in the choroid plexus epithelial cells in Alzheimer's disease. © 2013 Springer Basel.
2014-06-10T10:43:14Z
2014-06-10T10:43:14Z
2013
2014-06-10T10:43:15Z
artículo
Cellular and Molecular Life Sciences 70: 2787- 2797 (2013)
http://hdl.handle.net/10261/98100
10.1007/s00018-013-1300-x
eng
closedAccess
Birkhäuser Verlag