2024-03-29T14:21:34Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/581272020-11-19T15:09:01Zcom_10261_64com_10261_1col_10261_317
Deletion of LCE3C and LCE3B is a susceptibility factor for psoriatic arthritis: A study in Spanish and Italian populations and meta-analysis
Docampo, E.
Giardina, E.
Riveira-Muñoz, Eva
Cid, R. de
Escaramís, G.
Perricone, C.
Fernández-Sueiro, J. L.
Maymõ, J.
González-Gay, M. A.
Blanco, Francisco J.
Hüffmeier, U.
Lisbona, M. P.
Martín, J.
Carracedo, A.
Reis, A.
Rabionet, R.
Novelli, Giuseppe
Estivill, Xavier
Objective The LCE3C-LCE3B-del variant is associated with psoriasis and rheumatoid arthritis. Its role in psoriatic arthritis (PsA) is unclear, however, as shown by 3 recent studies with contradictory results. In order to investigate whether LCE3C-LCE3B-del constitutes a risk factor for PsA susceptibility, we first tested this variant in patients with PsA from Spanish and Italian populations and then performed a meta-analysis including the previous case-control studies. Methods We genotyped LCE3C-LCE3B-del and its tag single-nucleotide polymorphism (SNP), rs4112788, in an original discovery cohort of 424 Italian patients with PsA and 450 unaffected control subjects. A Spanish replication cohort consisting of 225 patients with PsA and 469 control subjects was also genotyped. A meta-analysis considering 7,758 control subjects and 2,325 patients with PsA was also performed. Results We observed a significant association between PsA and the LCE3C-LCE3B-del tag SNP in the Italian and Spanish cohorts, with an overall corrected P value of 0.00019 and a corresponding odds ratio of 1.35 (95% confidence interval 1.14-1.59). Stratified analyses by subphenotype indicated a stronger association for patients with oligoarticular disease. Meta-analysis including data from all previous published studies confirmed an association of PsA with the LCE3C-LCE3B-del tag SNP. Conclusion LCE3C-LCE3B-del is a susceptibility factor for PsA, confirming the existence of a shared risk factor involving the epidermal skin barrier in autoimmune disorders. Copyright © 2011 by the American College of Rheumatology.
2012-10-16T11:37:47Z
2012-10-16T11:37:47Z
2011
2012-10-16T11:37:47Z
artículo
Arthritis and Rheumatism 63: 1860- 1865 (2011)
http://hdl.handle.net/10261/58127
10.1002/art.30340
eng
closedAccess
John Wiley & Sons