2024-03-28T15:58:12Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/364652016-06-28T10:19:13Zcom_10261_54com_10261_1col_10261_307
Changes in molecular isoform distribution of acetylcholinesterase in rat cortex and cerebrospinal fluid after intracerebroventricular administration of amyloid beta-peptide
Sáez-Valero, Javier
Ceballos, María L. de
Small, David H.
Felipe, Carmen de
4 pages, 3 figures. - PMID: 12044655 [PubMed - indexed for MEDLINE]
Previous studies have shown that an abnormal salt-soluble form of G(1) acetylcholinesterase (AChE) is increased in the Alzheimer's disease (AD) brain. The aim of the present study was to examine changes in AChE activity in an in vivo model of beta-amyloid peptide (A beta) administration. Rats received intracerebroventricular injections of A beta(25-35) (20 microg/day for seven days). Levels of AChE were measured in cerebral cortex and cerebrospinal fluid (CSF) after two months. A beta(25-35) administration did not alter total AChE activity in the cerebral cortex or CSF. However, analysis of salt-extractable AChE isoforms revealed an increase in the proportion of G(1) in both cortex and CSF, similar to that previously observed in AD patients. The results support the view that changes in AChE isoform pattern in the AD brain are a direct consequence of A beta accumulation
2011-06-02T14:50:53Z
2011-06-02T14:50:53Z
2002
artículo
Neuroscience Letters 325: 199-202 (2002)
0304-3040
http://hdl.handle.net/10261/36465
1872-7972
eng
http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6T0G-45JYHPR-2-K&_cdi=4862&_user=4221266&_pii=S0304394002002823&_origin=browse&_zone=rslt_list_item&_coverDate=06%2F14%2F2002&_sk=996749996&wchp=dGLbVzb-zSkWA&md5=eea3cf2f0bce99cb62b70f35c7b486bf&ie=/sdarticle.pdf
closedAccess
Elsevier